Structural brain correlates in major depression, anxiety disorders and post-traumatic stress disorder: A voxel-based morphometry meta-analysis

The high comorbidity of Major Depressive Disorder (MDD), Anxiety Disorders (ANX), and Posttraumatic Stress (PTSD) has hindered the study their structural neural correlates. authors analyzed specific common grey matter volume (GMV) characteristics by comparing them with healthy controls (HC). meta-analysis voxel-based morphometry (VBM) studies showed unique GMV diminutions for each disorder (p < 0.05, corrected) less robust smaller across diagnostics 0.01, uncorrected). Pairwise comparison between disorders differences in MDD versus ANX PTSD. These results endorse hypothesis that clinical features characterizing MDD, ANX, PTSD are also reflected